Zlecenie 8064744 - Nowe, małocząsteczkowe leki immunomodulujące w terapii...

mat on Jurkat T cell line Mass spec based approach for comprehensively profiling native kinases in cell or tissue lysates. Based on a desthiobiotin ATP (or ADP) acyl phosphate probe to covalently modify kinases in the active site. Provides the ability to broadly and quantitatively profile native protein and lipid kinases in cell or tissue lysates, without the need for recombinant protein expression or substrate-based assay development. Possible to use to test selectivity of compounds on human PBMC in the live cell format. Option 1) 2 compounds, 2 dozes Option 2) 4 compounds, 1 dose