Zlecenie 8915108 - Nowa terapia celowana nowotworów z delecją genu MTAP 1.1...
(zakończone) | Zamówienie 8915108|
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źródło | Internet |
data publikacji | 2022-05-19 |
przedmiot zlecenia | Nowa terapia celowana nowotworów z delecją genu MTAP 1.1 Animals CB.17 SCID mice, age-matched, provided by the Contractor (N=10 per group, maximum 90 mice in a single study). The contractor must declare the possibility to utilize up to 180 mice in two efficacy studies within 12 months. 1.2 Cell lines Animals will be inoculated subcutaneously with DoHH-2 or BxPC-3 cell lines. The contractor should provide information on the availability of validated models (without the need for a pilot study assessing growth kinetics). The contractor must offer BxPC-3 and DoHH-2 cell line xenografts with the first possible slot for the study start in June 2022. 1.3 Compounds administration The compounds will be provided by the Sponsor together with formulation instructions. Compounds will be prepared freshly before dosing. Compounds or formulation will be administered per os (PO) once daily (QD) or intravenously (IV) every other day (EOD), for about 3-4 weeks (the price should include dosing during weekends). • The Sponsor reserves the right to perform two similar experiments within 12 months. • The Sponsor might design the experiments either with the use of BxPC-3 or DoHH-2 xenograft models, with preferred dosing schedule and the number of experimental groups which will not exceed 18 in two studies. • The maximum number of groups with the compounds administrated PO in QD scheme will be 14, whereas the maximum number of groups dosed IV in EOD scheme will be 4, in two studies. 1.4 Evaluated parameters Clinical signs and body weight will be monitored daily throughout the dosing period. Tumor volume (TV) will be measured two-three times per week. Contractor should inform about the availability of the data during the study course and about the frequency of updates. 1.5 Sample collection and shipment Terminal blood (plasma preparation) and tumor sampling in one or two timepoints post the last administration (e.g. 4h and 24h). Samples will be stored at -80oC until shipment on dry ice to Sponsor, which should be organized as soon as possible after the experiment. Shipment costs to Poland should be included in the quotation. It has to be stressed that the permission from Central Veterinary Inspectorate is obligatory to import biological samples from outside the European Union, which will be the responsibility of the Sponsor. 1.6 Report Non-GLP study and report. |
branża | Laboratoria |
podbranża | usługi laboratoryjne |
kody CPV | 73110000 |
forma | zapytanie ofertowe |
typ zlecenia | usługi, wykonanie |
kraj realizacji | Polska |
województwo realizacji | Małopolskie |
kraj organizatora | Polska |
województwo organizatora | Małopolskie |